Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 10/20 | 0.38 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRG | P48443 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | OGT | O15294 | 1/20 | 0.33 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6728577 | 0.86 | SIGMAR1 (0.50) | RXRARXRBRXRGLMNAMAPT | |
| SCHEMBL7622139 | 0.82 | HSD17B1 (0.43) | HSD17B1HSD17B2LMNAMAPTSIGMAR1 | |
| SCHEMBL7621271 | 0.79 | RXRA (0.38) | RXRARXRBRXRGLMNAMAPT | |
| SCHEMBL7779720 | 0.79 | HSD17B1 (0.38) | HSD17B1HSD17B2LMNAMAPTSIGMAR1 | |
| SCHEMBL6723974 | 0.77 | SIGMAR1 (0.47) | RXRARXRBRXRGLMNAMAPT | |
| SCHEMBL6719323 | 0.76 | SIGMAR1 (0.41) | RXRARXRBRXRGLMNASIGMAR1 | |
| SCHEMBL6719427 | 0.74 | SIGMAR1 (0.44) | RXRARXRBRXRGLMNASIGMAR1 | |
| SCHEMBL6724017 | 0.72 | SIGMAR1 (0.61) | RXRARXRBRXRGLMNAMAPT | |
| SCHEMBL6724170 | 0.70 | SIGMAR1 (0.52) | LMNAMAPTSIGMAR1 | |
| SCHEMBL6723967 | 0.70 | SIGMAR1 (0.52) | LMNAMAPTSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251948-B1 | Tri-and tetra-substituted guanidines and their use as excitatory amino acid antagonists | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON | 2001-06-26 | — | — | US | claimed |
| US-5559154-A | Tri- and tetra-substituted guanidines and their use as excitatory amino acid antagonists | OREGON STATE BOARD OF HIGHER EDUCATION | 1996-09-24 | — | — | US | claimed |