SCHEMBL7779858

SCHEMBL7779858

O=[C]C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
THRB P10828 1/20 0.38
CA2 P00918 2/20 0.35
CA1 P00915 1/20 0.32
MMP1 P03956 1/20 0.32
MMP2 P08253 1/20 0.32
MMP9 P14780 1/20 0.32
MMP8 P22894 1/20 0.32
MMP13 P45452 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL957653 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL955673 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL7782669 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL957475 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL6656018 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL953592 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL956942 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL465609 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL536268 1.00 LMNA (0.38) LMNATHRBCA2CA1MMP1
SCHEMBL835510 0.97 LMNA (0.33) LMNATHRBCA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0825167-B1 COMPOUNDS AND SURFACTANTS ASAHI DENKA KOGYO KK (JP) 2001-10-04 EP disclosed
US-5929290-A A HYDROPHILIC POLYETHER HAVING A FLUORO-SUBSTITUTED ALKYL END GROUP AND A (METH)ALLYL GLYCIDYL END GROUP; EMULSIFIERS AND DISPERSANTS FOR EMULSION AND SUSPENSION POLYMERIZATION, RESP.; RESIN REFORMING AGENTS; ANTISOILANTS FOR POLYESTERS ASAHI DENKA KOGYO K. K. (JP) 1999-07-27 US disclosed
EP-0825167-A1 COMPOUNDS AND SURFACTANTS ASAHI DENKA KOGYO KABUSHIKI KAISHA (JP) 1998-02-25 EP disclosed