Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201819 | 0.94 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7780289 | 0.91 | HTR1A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7780294 | 0.91 | SLC6A4 (0.47) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7784876 | 0.91 | HTR1A (0.43) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7780297 | 0.89 | ADRA2A (0.46) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7788865 | 0.88 | HTR1A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8126464 | 0.88 | DRD2 (0.41) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7785338 | 0.86 | HTR1A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8124382 | 0.86 | HTR1A (0.45) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7788881 | 0.85 | HTR1A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1093127-C | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2002-10-23 | — | — | CN | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| CN-1264379-A | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2000-08-23 | — | — | CN | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |