Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 3/20 | 0.63 |
| ▸ | STS | P08842 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | P4HB | P07237 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16396165 | 0.91 | P4HB (0.63) | VNN1STSALDH1A1P4HBMAPT | |
| SCHEMBL2303699 | 0.84 | STS (0.72) | STSALDH1A1GAAMAPTMEN1 | |
| SCHEMBL3469060 | 0.84 | VNN1 (0.63) | VNN1ALDH1A1GAAMAPTMEN1 | |
| SCHEMBL10969744 | 0.84 | ALDH1A1 (0.68) | STSALDH1A1GAAMAPTMEN1 | |
| SCHEMBL4201889 | 0.82 | ATM (0.63) | VNN1ALDH1A1GSK3BL3MBTL1 | |
| SCHEMBL9078419 | 0.82 | HPGD (0.66) | VNN1STSALDH1A1P4HBLMNA | |
| SCHEMBL4709783 | 0.82 | VNN1 (0.52) | VNN1STSALDH1A1P4HBMAPT | |
| SCHEMBL8937532 | 0.81 | P4HB (0.50) | VNN1ALDH1A1P4HBMAPK1GSK3B | |
| SCHEMBL8937528 | 0.81 | P4HB (0.50) | VNN1ALDH1A1P4HBMAPK1GSK3B | |
| SCHEMBL4709037 | 0.81 | VNN1 (0.51) | VNN1STSALDH1A1P4HBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-0288189-B1 | IMPROVEMENTS IN OR RELATING TO LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1992-11-11 | — | — | EP | disclosed |
| US-4853398-A | ANTIALLERGENS | ELI LILLY AND COMPANY (US) | 1989-08-01 | — | — | US | disclosed |
| EP-0288189-A1 | Improvements in or relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1988-10-26 | — | — | EP | disclosed |