Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 8/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.46 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4244096 | 0.91 | L3MBTL1 (0.57) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL12825474 | 0.84 | KDR (0.62) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL16202045 | 0.84 | KDR (0.62) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL7783065 | 0.84 | ALDH1A1 (0.54) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL8773803 | 0.82 | ALDH1A1 (0.53) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL8683754 | 0.82 | ALDH1A1 (0.47) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL8941516 | 0.81 | MAPT (0.59) | ALDH1A1POLBL3MBTL1MAPTGAA | |
| SCHEMBL8773158 | 0.80 | MAPT (0.65) | ALDH1A1POLBL3MBTL1MAPTGAA | |
| SCHEMBL29607042 | 0.80 | MAPT (0.65) | ALDH1A1POLBL3MBTL1MAPTGAA | |
| SCHEMBL7775883 | 0.79 | MAPT (0.48) | ALDH1A1POLBL3MBTL1MAPTKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794177-B1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | AMERICAN CYANAMID CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6087498-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-5977363-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0794177-A1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | American Cyanamid Company (US) | 1997-09-10 | — | — | EP | disclosed |