Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 9/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | TNNI3K | Q59H18 | 7/20 | 0.47 |
| ▸ | BRAF | P15056 | 6/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8773803 | 0.99 | ALDH1A1 (0.53) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL4244096 | 0.89 | L3MBTL1 (0.57) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL7780979 | 0.84 | ALDH1A1 (0.52) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL4832711 | 0.83 | TRPV1 (0.47) | MAPTKDRMAPK14TNNI3KBRAF | |
| SCHEMBL8683809 | 0.82 | KDR (0.48) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL12825474 | 0.82 | KDR (0.62) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL16202045 | 0.82 | KDR (0.62) | ALDH1A1POLBL3MBTL1MAPTKDR | |
| SCHEMBL3457474 | 0.82 | MAPT (0.58) | ALDH1A1POLBL3MBTL1MAPTNTRK1 | |
| SCHEMBL7540746 | 0.81 | TRPV1 (0.56) | ALDH1A1POLBL3MBTL1MAPTRAB9A | |
| SCHEMBL692108 | 0.80 | CYP1A2 (0.53) | L3MBTL1RAB9AMAP2K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794177-B1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | AMERICAN CYANAMID CO (US) | 2001-10-10 | — | — | EP | disclosed |
| US-6087498-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| US-5977363-A | Process for the preparation of unsymmetrical 4,6-bis(aryloxy) pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0794177-A1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | American Cyanamid Company (US) | 1997-09-10 | — | — | EP | disclosed |