Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781192 | 0.87 | DRD2 (0.44) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7788385 | 0.86 | DRD2 (0.46) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7790219 | 0.85 | DRD2 (0.43) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7781213 | 0.85 | DRD2 (0.46) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7785697 | 0.82 | ADRA1D (0.32) | DRD2ADRA1DADRA1AADRA1BDRD3 | |
| SCHEMBL11520474 | 0.79 | DRD2 (0.57) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL2957887 | 0.73 | DRD2 (0.51) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL2956868 | 0.72 | ADRA1D (0.49) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7788401 | 0.72 | DRD2 (0.78) | DRD2DRD1ADRA1DADRA1AADRA1B | |
| SCHEMBL7781196 | 0.72 | DRD2 (0.78) | DRD2DRD1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717620-B1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0717620-A4 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0717620-A1 | SUBSTITUTED 2-AMINOTETRALINS | Discovery Therapeutics, Inc. (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995004532-A1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC. (US) | 1995-02-16 | — | — | WO | disclosed |
| US-5382596-A | Useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals | WHITBY RESEARCH, INC. (US) | 1995-01-17 | — | — | US | disclosed |