Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.49 |
| ▸ | RAF1 | P04049 | 4/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.49 |
| ▸ | KMO | O15229 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885604 | 0.92 | RAF1 (0.49) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL7776445 | 0.87 | RAF1 (0.46) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL7781852 | 0.87 | KDR (0.48) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL8773800 | 0.87 | KDR (0.48) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL679527 | 0.86 | KDR (0.49) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL679617 | 0.85 | RAF1 (0.45) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL8683809 | 0.82 | KDR (0.48) | KDRRAF1BRAFMAPK3 | |
| SCHEMBL679549 | 0.82 | RAF1 (0.43) | KDRRAF1BRAFMAPK3KMO | |
| SCHEMBL3167291 | 0.82 | KDR (0.74) | KDRRAF1BRAFMAPK3 | |
| SCHEMBL8773810 | 0.80 | KDR (0.46) | KDRRAF1BRAFMAPK3KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902020-B1 | Improved process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds | BASF AG (DE) | 2001-11-28 | — | — | EP | disclosed |
| EP-0902020-A1 | Improved process for the preparation of unsymmetrical 4,6-bis (aryloxy) pyrimidine compounds | American Cyanamid Company (US) | 1999-03-17 | — | — | EP | disclosed |
| US-5849910-A | Process for the preparation of unsymmetrical 4,6-bis aryloxy-pyrimidine compounds | AMERICAN CYANAMID COMPANY (US) | 1998-12-15 | — | — | US | disclosed |