Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | RAF1 | P04049 | 4/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679527 | 0.93 | KDR (0.49) | KDRBRAFRAF1MAPK3PLA2G7 | |
| SCHEMBL8773810 | 0.89 | KDR (0.46) | KDRBRAFRAF1MAPK3FLT1 | |
| SCHEMBL7885604 | 0.86 | RAF1 (0.49) | KDRBRAFRAF1MAPK3PLA2G7 | |
| SCHEMBL6938479 | 0.84 | KDR (0.48) | KDRBRAFPLA2G7FLT1FLT4 | |
| SCHEMBL7781852 | 0.81 | KDR (0.48) | KDRBRAFRAF1MAPK3FLT1 | |
| SCHEMBL7776445 | 0.81 | RAF1 (0.46) | KDRBRAFRAF1MAPK3PLA2G7 | |
| SCHEMBL8773800 | 0.81 | KDR (0.48) | KDRBRAFRAF1MAPK3FLT1 | |
| SCHEMBL8199428 | 0.80 | KDR (0.44) | KDRBRAFRAF1MAPK3PLA2G7 | |
| SCHEMBL7791086 | 0.79 | KDR (0.49) | KDRBRAFRAF1MAPK3PLA2G7 | |
| SCHEMBL3366738 | 0.79 | EGFR (0.46) | KDRBRAFRAF1PLA2G7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0794177-A1 | Process for the preparation of unsymmertical 4,6-Bis (aryloxy pyrimidine compounds | American Cyanamid Company (US) | 1997-09-10 | — | — | EP | disclosed |