Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7270380 | 0.89 | TSHR (0.40) | HPGDTSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7186166 | 0.79 | TBXAS1 (0.45) | TSHRALDH1A1MAPTLMNA | |
| SCHEMBL5672910 | 0.78 | MAPK1 (0.47) | HPGDALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL2091687 | 0.73 | ALDH1A1 (0.33) | HPGDTSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL2097744 | 0.73 | ALDH1A1 (0.33) | HPGDTSHRALDH1A1MAPK1NPSR1 | |
| SCHEMBL4888615 | 0.73 | MAPK1 (0.41) | TSHRALDH1A1SMN1; SMN2LMNAMAPK1 | |
| SCHEMBL11266906 | 0.73 | GABRA5 (0.47) | HPGDTSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4077786 | 0.72 | KCNH2 (0.44) | TSHRALDH1A1SMN1; SMN2MIFLMNA | |
| SCHEMBL15568312 | 0.72 | TBXAS1 (0.43) | HPGDTSHRALDH1A1SMN1; SMN2MIF | |
| SCHEMBL6643882 | 0.71 | SMN1; SMN2 (0.55) | HPGDALDH1A1SMN1; SMN2LMNALTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1135377-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-09-26 | — | — | EP | disclosed |
| WO-2000034254-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-06-15 | — | — | WO | disclosed |