SCHEMBL7783997

SCHEMBL7783997

C=CCc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1CC=C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.44
GABRB2 P47870 1/20 0.44
GPR35 Q9HC97 4/20 0.39
XDH P47989 1/20 0.37
MEN1 O00255 3/20 0.37
ALDH1A1 P00352 3/20 0.37
MAPT P10636 3/20 0.37
RECQL P46063 3/20 0.37
KMT2A Q03164 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
HPGD P15428 2/20 0.37
SNCA P37840 1/20 0.37
KDM4E B2RXH2 1/20 0.37
TTR P02766 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
ALOX15 P16050 1/20 0.37
ALOX12 P18054 1/20 0.37
MAPK1 P28482 1/20 0.37
PMP22 Q01453 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8668081 0.82 ALDH1A1 (0.36) GABRA1GABRB2MEN1ALDH1A1MAPT
SCHEMBL7792237 0.77 HCAR3 (0.43) GABRA1GABRB2MEN1ALDH1A1MAPT
SCHEMBL28565292 0.77 GABRA1 (0.40) GABRA1GABRB2GPR35MEN1ALDH1A1
SCHEMBL7645214 0.76 GABRA1 (0.41) GABRA1GABRB2MEN1ALDH1A1MAPT
SCHEMBL5141227 0.75 GPR35 (0.54) GABRA1GABRB2GPR35XDHMEN1
SCHEMBL30853117 0.75 GPR35 (0.54) GABRA1GABRB2GPR35XDHMEN1
SCHEMBL11006259 0.75 GABRA1 (0.43) GABRA1GABRB2GPR35MEN1ALDH1A1
SCHEMBL15667473 0.74 GPR35 (0.61) GABRA1GABRB2GPR35XDHMEN1
SCHEMBL16345283 0.74 ERN1 (0.54) GABRA1GABRB2GPR35XDHMEN1
SCHEMBL6445118 0.74 GABRA1 (0.47) GABRA1GABRB2GPR35XDHMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630883-B1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS (IL) 1998-09-16 EP claimed
US-5602283-A Multi-stage process for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1997-02-11 US claimed
EP-0630883-A1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1994-12-28 EP claimed
CN-117049967-A Preparation method and active application of 2, 6-dinitro-3, 4-dimethylphenol derivative 西华大学 2023-11-14 CN disclosed
EP-0870756-B1 Process for the preparation of 3,4-disubstituted dinitroanilines CFPI NUFARM (FR) 2001-11-07 EP disclosed
US-6028226-A Process for 3,4-disubstituted dinitroanilines CFPI AGRO (FR) 2000-02-22 US disclosed
EP-0870756-A1 Process for the preparation of 3,4-disubstituted dinitroanilines CFPI AGRO (FR) 1998-10-14 EP disclosed
EP-0630883-B1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS (IL) 1998-09-16 EP disclosed
US-5602283-A Multi-stage process for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1997-02-11 US disclosed
US-5602283-A Multi-stage process for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1997-02-11 US disclosed
US-5475148-A Process and intermediate to prepare N-alkyl-3,4-dialkyl-2,6-dinitro-anilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1995-12-12 US disclosed
EP-0630883-A1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1994-12-28 EP disclosed
EP-0630883-A1 Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines AGAN CHEMICAL MANUFACTURERS LTD. (IL) 1994-12-28 EP disclosed