Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852161 | 1.00 | TP53 (0.48) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL14382085 | 0.98 | TP53 (0.44) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL23870582 | 0.91 | TP53 (0.38) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL29067960 | 0.87 | — | — | |
| SCHEMBL29067957 | 0.87 | — | — | |
| SCHEMBL23503456 | 0.87 | TP53 (0.37) | TP53KDM4EGMNNLMNAMAPT | |
| SCHEMBL20354169 | 0.85 | KDM4E (0.42) | TP53KDM4E | |
| SCHEMBL5101014 | 0.80 | KDM4E (0.39) | TP53KDM4E | |
| SCHEMBL28622321 | 0.78 | ALDH1A1 (0.38) | TP53KDM4ELMNAMAPT | |
| SCHEMBL7906892 | 0.78 | ALDH1A1 (0.38) | TP53KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0363108-B1 | Wash solution containing a cationic surfactant and its use in chlamydial and gonococcal determinations | EASTMAN KODAK CO (US) | 1994-07-13 | — | — | EP | claimed |
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | PHENEX PHARMACEUTICALS AG (DE) | 2019-05-28 | — | — | US | disclosed |
| CN-107076728-A | Analytical method for diluting biological sample components | 立佳有限公司 | 2017-08-18 | — | — | CN | disclosed |
| US-20150175562-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | PHENEX PHARMACEUTICALS AG (DE) | 2015-06-25 | — | — | US | disclosed |
| EP-2855440-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | Phenex Pharmaceuticals AG (DE) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013178362-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | PHENEX PHARMACEUTICALS AG (DE) | 2013-12-05 | — | — | WO | disclosed |
| CN-1100534-C | 2-(1H-4(5)-imidazoyl cyclopropyl derivatives | GLIATECH INC (US) | 2003-02-05 | — | — | CN | disclosed |
| EP-0837679-B1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 2001-10-24 | — | — | EP | disclosed |
| US-6008240-A | AN ANTAGONIST OF HISTAMINE H3 RECEPTORS; FOR TREATING ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE (HYPER OR HYPOTENSION), GASTROINTESTINAL DISORDERS, CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-12-28 | — | — | US | disclosed |
| US-5990317-A | HISTAMINE H3 RECEPTOR ANTAGONIST FOR TREATING CNS DISORDERS INVOLVING ATTENTION OR COGNITIVE DISORDERS | GLIATECH, INC. (US) | 1999-11-23 | — | — | US | disclosed |
| EP-0837679-A4 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH INC (US) | 1999-03-03 | — | — | EP | disclosed |
| CN-1192143-A | 2-(1H-4(5)-imidazoyl cyclopropyl derivatives | GLIATECH INC (US) | 1998-09-02 | — | — | CN | disclosed |
| EP-0837679-A1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | Gliatech, Inc. (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996038141-A1 | 2-(1H-4(5)-IMIDAZOYL) CYCLOPROPYL DERIVATIVES | GLIATECH, INC. (US) | 1996-12-05 | — | — | WO | disclosed |
| CN-1113436-A | Potentiation of drug response | LILLY CO ELI (US) | 1995-12-20 | — | — | CN | disclosed |
| CN-1104889-A | Cessation of tobacco use | LILLY CO ELI (US) | 1995-07-12 | — | — | CN | disclosed |
| US-4990666-A | Contacting with Raney cobalt; heating, pressurization | W. R. GRACE & CO.-CONN. (US) | 1991-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175562-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | RORA, RORB, RORC | TP53 3409/4885KDM4E 2241/4885GMNN 4522/4885 |
| US-10301272-B2 | Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ] | RORA, RORB, RORC | TP53 3471/4885KDM4E 2217/4885GMNN 4569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.