Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28002067 | 0.76 | HSD17B1 (0.45) | SMN1; SMN2LMNAKMT2ATP53MAPT | |
| SCHEMBL7790476 | 0.76 | LMNA (0.46) | SMN1; SMN2LMNACYP2C19KMT2AMAPT | |
| SCHEMBL7784589 | 0.73 | HTR3E (0.38) | SMN1; SMN2LMNACYP2D6CYP2C19MAPT | |
| SCHEMBL7784546 | 0.73 | POLB (0.50) | SMN1; SMN2LMNACYP2C19MAPTEPHX2 | |
| SCHEMBL28006794 | 0.71 | NOTUM (0.51) | SMN1; SMN2LMNACYP2C19KMT2AMAPT | |
| SCHEMBL7793305 | 0.70 | PDE7A (0.41) | LMNACYP2D6CYP2C19MAPTNPC1 | |
| SCHEMBL177205 | 0.70 | — | — | |
| SCHEMBL12476221 | 0.70 | CHRM2 (0.42) | LMNACYP2D6KMT2ACHRM3SERPINE1 | |
| Ammonia Solution, Strong SCHEMBL28770241 | 0.68 | — | — | |
| SCHEMBL28780475 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046214-A1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-08-10 | — | — | WO | disclosed |