Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8166679 | 0.81 | FDPS (0.62) | NPC1RAB9AMAPTMAPK1KMT2A | |
| SCHEMBL5155756 | 0.80 | FDPS (0.47) | NPC1RAB9AFDPS | |
| SCHEMBL7793597 | 0.80 | FDPS (0.60) | NPC1RAB9AMAPTCA12CA1 | |
| SCHEMBL12890441 | 0.76 | KMT2A (0.52) | NPC1RAB9AMAPTNFKB1MAPK1 | |
| SCHEMBL9693888 | 0.76 | NPC1 (0.60) | NPC1RAB9AMAPTNFKB1MAPK1 | |
| SCHEMBL10695805 | 0.76 | NPC1 (0.60) | NPC1RAB9AMAPTNFKB1MAPK1 | |
| SCHEMBL1631701 | 0.74 | ALDH1A1 (0.46) | NPC1RAB9AMAPTNFKB1MAPK1 | |
| SCHEMBL7793553 | 0.74 | GRM5 (0.50) | — | |
| SCHEMBL7697932 | 0.74 | MAPT (0.51) | NPC1RAB9AMAPTNFKB1MAPK1 | |
| SCHEMBL4034758 | 0.73 | NPC1 (0.62) | NPC1RAB9AMAPTNFKB1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762883-B1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 2001-11-14 | — | — | EP | claimed |
| EP-0762883-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033466-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1995-12-14 | — | — | WO | claimed |
| US-5866556-A | BONE DISORDERS | LEIRAS OY (FI) | 1999-02-02 | — | — | US | disclosed |