SCHEMBL7784756

SCHEMBL7784756

Cc1ccc2c(Cl)cc(S(=O)(=O)NCCc3c[nH]c4ccccc34)c(O)c2n1

nearest known ligand 0.57

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MGAM O43451 1/20 0.57
CYP19A1 P11511 2/20 0.51
RAD51 Q06609 1/20 0.49
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
KCNA5 P22460 1/20 0.45
KCNH2 Q12809 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8311550 0.82 MAPT (0.49)
SCHEMBL7689574 0.81 MAPT (0.47) KMT2A
SCHEMBL5229726 0.80 MGAM (0.71) MGAMCYP19A1RAD51MEN1KMT2A
SCHEMBL7686086 0.79 KDM4E (0.57)
SCHEMBL2944815 0.79 MGAM (0.76) MGAMCYP19A1RAD51MEN1KMT2A
SCHEMBL7691423 0.79 TDP1 (0.50) MEN1KMT2A
SCHEMBL7690995 0.78 MAPT (0.49) MEN1KMT2A
SCHEMBL7686834 0.78 ALDH1A1 (0.52) MEN1KMT2A
SCHEMBL7692330 0.77 MAPT (0.48)
SCHEMBL2949600 0.77 NR3C1 (0.67) MGAMCYP19A1RAD51MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6252080-B1 HERPES, CYTOMEGALO VIRUS PHARMACIA & UPJOHN COMPANY 2001-06-26 US disclosed