Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 13/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5203295 | 0.94 | HTR1A (0.58) | HTR1AHTR7 | |
| SCHEMBL7784855 | 0.90 | DRD2 (0.53) | DRD2HTR1AHTR7 | |
| SCHEMBL7784873 | 0.89 | HTR1A (0.55) | DRD2HTR1A | |
| SCHEMBL7788878 | 0.86 | HTR1A (0.65) | DRD2HTR1AHTR7 | |
| SCHEMBL5206035 | 0.86 | HTR1A (0.56) | DRD2HTR1A | |
| SCHEMBL7780289 | 0.84 | HTR1A (0.45) | DRD2HTR1A | |
| SCHEMBL5200827 | 0.84 | HTR1A (0.59) | DRD2HTR1AHTR7 | |
| SCHEMBL7787379 | 0.82 | DRD2 (0.57) | DRD2HTR1AHTR7 | |
| SCHEMBL7784874 | 0.82 | SLC6A4 (0.48) | HTR1A | |
| SCHEMBL7784876 | 0.80 | HTR1A (0.43) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |