Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 4/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784855 | 0.94 | DRD2 (0.53) | HTR1ADRD2HTR6KCNH2 | |
| SCHEMBL5203295 | 0.90 | HTR1A (0.58) | HTR1AKCNH2 | |
| SCHEMBL7784873 | 0.90 | HTR1A (0.55) | HTR1ADRD2 | |
| SCHEMBL5200827 | 0.88 | HTR1A (0.59) | HTR1ADRD2HTR6KCNH2 | |
| SCHEMBL7784870 | 0.86 | DRD2 (0.53) | HTR1ADRD2 | |
| SCHEMBL5232348 | 0.85 | HTR1A (0.65) | HTR1ADRD2HTR6KCNH2 | |
| SCHEMBL5201819 | 0.83 | ADRA2A (0.51) | — | |
| SCHEMBL5203900 | 0.81 | DRD2 (0.57) | HTR1ADRD2HTR6KCNH2 | |
| SCHEMBL5201824 | 0.81 | ADRA2A (0.47) | HTR1A | |
| SCHEMBL7785358 | 0.80 | SLC6A4 (0.54) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |