Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7784862 | 0.95 | SLC6A4 (0.47) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7780259 | 0.92 | SLC6A4 (0.53) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7784867 | 0.92 | ADRA2A (0.59) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7785392 | 0.92 | SLC6A4 (0.53) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5204246 | 0.91 | KDM4E (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787588 | 0.91 | SLC6A4 (0.56) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7788884 | 0.90 | HTR1A (0.54) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL5233203 | 0.89 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL7787595 | 0.86 | DRD2 (0.47) | SLC6A4ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL7785348 | 0.86 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |