SCHEMBL7785876

SCHEMBL7785876

CC(C)(N)CC(=O)N[C@@H]1CSc2ccccc2N(Cc2ccc(-c3ccccc3NC(=O)N3CCOCC3)cc2)C1=O

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 4/20 0.47
AGTR1 P30556 1/20 0.47
XIAP P98170 1/20 0.42
F7 P08709 4/20 0.38
F3 P13726 4/20 0.38
F2 P00734 1/20 0.38
ALDH1A1 P00352 2/20 0.37
MAPT P10636 2/20 0.37
ABCB1 P08183 1/20 0.37
ABCG2 Q9UNQ0 1/20 0.37
GAA P10253 1/20 0.37
MME P08473 3/20 0.36
ACE P12821 3/20 0.36
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7791696 0.89 XIAP (0.41) GHSRAGTR1XIAPF7F3
SCHEMBL9108628 0.88 GHSR (0.37) GHSRAGTR1XIAPF7F3
SCHEMBL7794332 0.87 GHSR (0.63) GHSRAGTR1XIAP
SCHEMBL7785847 0.87 GHSR (0.51) GHSRAGTR1XIAPF7F3
SCHEMBL7785912 0.87 GHSR (0.51) GHSRAGTR1XIAPF7F3
SCHEMBL9274419 0.86 GHSR (0.47) GHSRAGTR1ALDH1A1MAPTABCB1
SCHEMBL7791984 0.85 GHSR (0.50) GHSRAGTR1XIAPF7F3
SCHEMBL9271723 0.82 GHSR (0.48) GHSRAGTR1XIAPF7F3
SCHEMBL9024510 0.82 GHSR (0.53) GHSRAGTR1XIAPF7F3
SCHEMBL9024508 0.82 GHSR (0.53) GHSRAGTR1XIAPF7F3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP claimed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US claimed
EP-0659179-A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1995-08-09 EP claimed
EP-0659179-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-06-28 EP claimed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO claimed
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed
US-5283241-A Animal growth regulators MERCK & CO., INC. (US) 1994-02-01 US disclosed