SCHEMBL7791984

SCHEMBL7791984

CC(C)(N)CC(=O)N[C@@H]1CSc2ccccc2N(Cc2ccc(-c3ccccc3NC(=O)NCCO)cc2)C1=O

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
GHSR Q92847 4/20 0.50
AGTR1 P30556 1/20 0.49
XIAP P98170 1/20 0.45
F7 P08709 7/20 0.41
F3 P13726 7/20 0.41
F2 P00734 3/20 0.41
MME P08473 3/20 0.39
ACE P12821 3/20 0.39
DRD2 P14416 2/20 0.37
DRD4 P21917 2/20 0.37
DRD3 P35462 2/20 0.37
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
DRD1 P21728 1/20 0.36
DRD5 P21918 1/20 0.36
HTR2A P28223 1/20 0.36
ADRA1A P35348 1/20 0.36
F10 P00742 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7785847 0.92 GHSR (0.51) GHSRAGTR1XIAPF7F3
SCHEMBL7785751 0.90 GHSR (0.45) GHSRAGTR1XIAPF7F3
SCHEMBL7792083 0.89 GHSR (0.64) GHSRAGTR1XIAPF7F3
SCHEMBL7785912 0.89 GHSR (0.51) GHSRAGTR1XIAPF7F3
SCHEMBL9107930 0.87 GHSR (0.44) GHSRAGTR1XIAPF7F3
SCHEMBL7785967 0.87 GHSR (0.67) GHSRAGTR1XIAP
SCHEMBL9388895 0.86 GHSR (0.49) GHSRAGTR1XIAPDRD2DRD4
SCHEMBL9104616 0.85 GHSR (0.43) GHSRAGTR1XIAPF7F3
SCHEMBL7785876 0.85 GHSR (0.47) GHSRAGTR1XIAPF7F3
SCHEMBL9103074 0.84 GHSR (0.44) GHSRAGTR1XIAPF7F3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP claimed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US claimed
EP-0659179-A4 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. MERCK & CO INC (US) 1995-08-09 EP claimed
EP-0659179-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO. INC. (US) 1995-06-28 EP claimed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO claimed
EP-0659179-B1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO INC (US) 2001-11-21 EP disclosed
US-5968924-A HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS MERCK & CO., INC. (US) 1999-10-19 US disclosed
WO-1994005634-A1 BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE MERCK & CO., INC. (US) 1994-03-17 WO disclosed
US-5283241-A Animal growth regulators MERCK & CO., INC. (US) 1994-02-01 US disclosed