Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.51 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.51 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6654828 | 0.86 | KDM4E (0.49) | KDM4EGNAI3GNAO1GNAI1CYP1A2 | |
| Hydrochloric Acid SCHEMBL27483203 | 0.85 | GNAI3 (0.50) | KDM4EGNAI3GNAO1GNAI1CYP1A2 | |
| SCHEMBL14979455 | 0.80 | TDP1 (0.46) | KDM4ETDP1CYP1A2KDM1AMAOA | |
| SCHEMBL6652163 | 0.80 | GNAI3 (0.44) | KDM4EGNAI3GNAO1GNAI1CYP1A2 | |
| SCHEMBL2466960 | 0.79 | KDM4E (0.87) | KDM4ECYP1A2CYP2D6CYP2C19SLC6A4 | |
| SCHEMBL14885856 | 0.78 | POLB (0.58) | KDM4ETDP1KDM1AMAOAMAOB | |
| SCHEMBL6652988 | 0.76 | KDM4E (0.48) | KDM4EGNAI3GNAO1GNAI1TDP1 | |
| SCHEMBL17484553 | 0.75 | KDM4E (0.54) | KDM4ECYP1A2CYP2D6CYP2C19SLC6A4 | |
| SCHEMBL28069803 | 0.75 | ALDH1A1 (0.59) | KDM4ETDP1KDM1AMAOAMAOB | |
| SCHEMBL8490059 | 0.73 | KDM4E (0.60) | KDM4ECYP1A2CYP2D6CYP2C19HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143971-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043011-A1 | SUBSTITUTED 1-(PIPERIDIN-4-YL)-3-(ARYL)-ISOTHIOUREAS, THEIR PREPARATION AND THERAPEUTIC USE | PIERRE FABRE MEDICAMENT (FR) | 2000-07-27 | — | — | WO | disclosed |