Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.38 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7800490 | 0.93 | MAP2K1 (0.50) | MAP2K1MAP2K2HPGDHSD17B10MRGPRX1 | |
| SCHEMBL5676551 | 0.87 | HPGD (0.55) | MAP2K1MAP2K2HPGDHSD17B10TGFBR1 | |
| SCHEMBL6035296 | 0.87 | ALDH1A1 (0.48) | MAP2K1HPGDTGFBR1ACVR1BACVRL1 | |
| SCHEMBL6035294 | 0.87 | HPGD (0.49) | MAP2K1HPGDTGFBR1MEN1KMT2A | |
| SCHEMBL6035385 | 0.87 | MAP2K1 (0.53) | MAP2K1MAP2K2HPGDHSD17B10MEN1 | |
| SCHEMBL7941506 | 0.86 | MEN1 (0.38) | MAP2K1MAP2K2HPGDHSD17B10MRGPRX1 | |
| SCHEMBL7785263 | 0.85 | KCNA3 (0.34) | MAP2K1MAP2K2HPGDHSD17B10MRGPRX1 | |
| SCHEMBL6035201 | 0.82 | ATM (0.50) | HPGDMEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL6035305 | 0.82 | RAB9A (0.49) | HPGDMEN1KMT2ALMNACNR1 | |
| SCHEMBL6036036 | 0.81 | CDK1 (0.55) | MAP2K1MAP2K2HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |