Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802481 | 0.90 | MEN1 (0.35) | KCNA3MAP2K1MAP2K2HPGDCYP1A2 | |
| SCHEMBL7800395 | 0.90 | HPGD (0.40) | KCNA3HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7787480 | 0.85 | MAP2K1 (0.44) | MAP2K1MAP2K2HPGDHSD17B10CYP3A4 | |
| SCHEMBL7802467 | 0.84 | ALDH1A1 (0.38) | HPGDHSD17B10CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7943547 | 0.81 | ALDH1A1 (0.35) | HPGDHSD17B10CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7938680 | 0.79 | MT-CO2 (0.32) | MT-CO2TOP1 | |
| SCHEMBL7803243 | 0.79 | MT-CO2 (0.36) | MT-CO2TOP1TACR1TP53FAAH | |
| SCHEMBL7800490 | 0.78 | MAP2K1 (0.50) | KCNA3MAP2K1MAP2K2HPGDHSD17B10 | |
| SCHEMBL7941487 | 0.78 | ALDH1A1 (0.33) | HPGDHSD17B10CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7787200 | 0.78 | PTGS2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140067-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-1140062-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040235-A2 | TREATMENT OF ASTHMA WITH MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-2000040237-A1 | ANTIVIRAL METHOD USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2000-07-13 | — | — | WO | disclosed |