Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ATM | Q13315 | 1/20 | 0.61 |
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.46 |
| ▸ | FNTB | P49356 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7787648 | 0.84 | NPC1 (0.56) | NPC1RAB9AATMCES2MAPK1 | |
| Hydrochloric Acid SCHEMBL8068701 | 0.83 | NPC1 (0.67) | NPC1RAB9AATMCES2MAPK1 | |
| Hydrochloric Acid SCHEMBL6131224 | 0.83 | NPC1 (0.65) | NPC1RAB9AATMCES2MAPK1 | |
| Hydrochloric Acid SCHEMBL31173710 | 0.83 | NPC1 (0.65) | NPC1RAB9AATMCES2MAPK1 | |
| SCHEMBL3530345 | 0.82 | NPC1 (0.54) | NPC1RAB9AATMCES2MAPK1 | |
| SCHEMBL29618182 | 0.82 | RAB9A (0.64) | NPC1RAB9AATMCES2MAPK1 | |
| SCHEMBL13648647 | 0.82 | RAB9A (0.64) | NPC1RAB9AATMCES2MAPK1 | |
| SCHEMBL741714 | 0.81 | NPC1 (0.62) | NPC1RAB9AATMCES2MAPK1 | |
| Hydrochloric Acid SCHEMBL3529156 | 0.81 | NPC1 (0.53) | NPC1RAB9AATMCES2MAPK1 | |
| Hydrochloric Acid SCHEMBL30343291 | 0.80 | NPC1 (0.65) | NPC1RAB9AATMMAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679939-B1 | Acyl substituted oxonol dyes | EASTMAN KODAK CO (US) | 2001-11-14 | — | — | EP | disclosed |
| EP-0679939-A1 | Acyl substituted oxonol dyes | EASTMAN KODAK COMPANY (US) | 1995-11-02 | — | — | EP | disclosed |
| US-5451494-A | Photographic elements containing acyl substituted oxonol dyes | EASTMAN KODAK COMPANY (US) | 1995-09-19 | — | — | US | disclosed |