SCHEMBL7788591

SCHEMBL7788591

O=C(c1ccccc1)c1ccc(Cl)c(S(=O)(=O)O)c1Cl

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 1/20 0.42
ALDH1A1 P00352 3/20 0.41
KMT2A Q03164 4/20 0.40
GAA P10253 2/20 0.40
MEN1 O00255 2/20 0.40
NR4A1 P22736 1/20 0.40
KDM4E B2RXH2 1/20 0.40
USP2 O75604 1/20 0.40
KEAP1 Q14145 1/20 0.40
NFE2L2 Q16236 1/20 0.40
MAPT P10636 2/20 0.40
LMNA P02545 2/20 0.40
ALOX15 P16050 1/20 0.40
MAPK13 O15264 1/20 0.39
MAPK12 P53778 1/20 0.39
MAPK11 Q15759 1/20 0.39
MAPK14 Q16539 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
PDF Q9HBH1 1/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14547179 0.84 TSHR (0.43) ALDH1A1KMT2AGAAMEN1KDM4E
SCHEMBL2987573 0.79 ALDH1A1 (0.50) AKR1C3ALDH1A1KMT2AGAAMEN1
SCHEMBL5073237 0.78 ALDH1A1 (0.59) AKR1C3ALDH1A1KMT2AGAAMEN1
SCHEMBL31380407 0.76 MEN1 (0.49) AKR1C3ALDH1A1KMT2AGAAMEN1
SCHEMBL10330714 0.76 PKM (0.32) ALDH1A1L3MBTL1PKM
SCHEMBL4448099 0.75 SRD5A2 (0.45) KMT2AMEN1NR4A1MAPTALOX15
SCHEMBL7782795 0.75 AKR1C3 (0.47) AKR1C3ALDH1A1KMT2AGAANR4A1
SCHEMBL11882116 0.75 AKR1C3 (0.55) AKR1C3ALDH1A1KMT2AGAAMEN1
SCHEMBL27550919 0.74 AKR1C3 (0.48) AKR1C3ALDH1A1KMT2AGAAMEN1
SCHEMBL18762937 0.73 F2 (0.37) ALDH1A1GAAMAPTLMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3395323-B1 METHOD FOR TREATING HAIR KAO CORP (JP) 2021-09-29 EP disclosed
US-20190038532-A1 METHOD FOR TREATING HAIR KAO CORPORATION (JP) 2019-02-07 US disclosed
EP-3395323-A1 HAIR TREATMENT METHOD Kao Corporation (JP) 2018-10-31 EP disclosed
EP-0672405-B1 Hair treatment composition KAO CORP (JP) 2001-11-14 EP disclosed
EP-0743847-B1 HAIR COSMETIC COMPOSITION KAO CORP (JP) 2001-05-30 EP disclosed
US-6217855-B1 ELASTICITY KAO CORPORATION (JP) 2001-04-17 US disclosed
EP-0662314-B1 Method of hair treatment KAO CORP (JP) 1999-11-03 EP disclosed
US-5683685-A NAPHTHALENESULFONIC ACID AND/OR BENZOPHENONE SULFONIC ACID WITH ANIONIC AND/OR AMPHOTERIC SURFACTANT WITH OIL KAO CORPORATION (JP) 1997-11-04 US disclosed
EP-0743847-A1 HAIR COSMETIC COMPOSITION Kao Corporation (JP) 1996-11-27 EP disclosed
EP-0529437-B1 Hair treatment composition KAO CORP (JP) 1996-07-17 EP disclosed
EP-0672405-A1 Hair treatment composition KAO CORPORATION (JP) 1995-09-20 EP disclosed
WO-1995020375-A1 HAIR COSMETIC COMPOSITION KAO CORPORATION (JP) 1995-08-03 WO disclosed
EP-0662314-A1 Method of hair treatment Kao Corporation (JP) 1995-07-12 EP disclosed
EP-0529437-A1 Hair treatment composition Kao Corporation (JP) 1993-03-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190038532-A1 METHOD FOR TREATING HAIR TYR, POLR1C, CA7 AKR1C3 239/4885ALDH1A1 201/4885KMT2A 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.