Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785724 | 0.93 | ALDH1A1 (0.40) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7784720 | 0.93 | ALDH1A1 (0.40) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7780359 | 0.92 | MAPT (0.41) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL7785715 | 0.91 | AKR1C3 (0.44) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7785688 | 0.91 | CRHBP (0.44) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL7785302 | 0.90 | HTT (0.46) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL7785084 | 0.88 | CRHBP (0.47) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7787830 | 0.88 | AKR1C3 (0.41) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7785645 | 0.88 | AKR1C3 (0.41) | ALDH1A1TDP1CYP3A4CYP2D6SLC6A2 | |
| SCHEMBL7780373 | 0.87 | LMNA (0.48) | ALDH1A1TDP1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |