Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7785523 | 0.89 | MAPT (0.40) | ABCB1ABCC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL7780620 | 0.86 | ALDH1A1 (0.40) | ALDH1A1MAPTMAPK1SMN1; SMN2HPGD | |
| SCHEMBL7785272 | 0.84 | KMT2A (0.41) | ABCB1ALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL7784922 | 0.84 | ALDH1A1 (0.36) | ABCB1ABCC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL7785657 | 0.83 | SMN1; SMN2 (0.37) | ABCB1ABCC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL7785504 | 0.79 | MEN1 (0.43) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL7780564 | 0.79 | MAPK1 (0.46) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL7785152 | 0.79 | MAPK1 (0.46) | ALDH1A1MAPTMAPK1SMN1; SMN2LMNA | |
| SCHEMBL7785512 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTMAPK1SMN1; SMN2HPGD | |
| SCHEMBL7795456 | 0.76 | CXCR2 (0.35) | ABCB1ABCC1ALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329405-B1 | AS ILEAL BILE ACID TRANSPORTER INHIBITOR, FOR THERAPY OF HYPERLIPEMIA | SANKYO COMPANY, LIMITED (JP) | 2001-12-11 | — | — | US | disclosed |
| CN-1287117-A | Cyclobutene derivatives, preparation method and therapeutic use thereof | SANKYO CO (JP) | 2001-03-14 | — | — | CN | disclosed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |