Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 5/20 | 0.43 |
| ▸ | RXRB | P28702 | 5/20 | 0.43 |
| ▸ | RXRG | P48443 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6741308 | 0.88 | EGFR (0.61) | EGFRPDK2RAB9A | |
| SCHEMBL5847620 | 0.88 | EGFR (0.61) | EGFRPDK2RAB9A | |
| SCHEMBL8441560 | 0.83 | S100A4 (0.43) | EGFRPDK2 | |
| SCHEMBL23302957 | 0.81 | LMNA (0.39) | EGFRMEN1RAB9AKMT2APDE4A | |
| SCHEMBL19125475 | 0.81 | PTGS2 (0.55) | EGFRPDK2MEN1KMT2A | |
| SCHEMBL29458425 | 0.79 | SLC6A9 (0.44) | PDK2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL24780613 | 0.78 | MEN1 (0.43) | MEN1RAB9AKMT2A | |
| SCHEMBL21178077 | 0.77 | EGFR (0.64) | EGFRRXRARXRBRXRG | |
| SCHEMBL18822403 | 0.76 | PTGS2 (0.50) | EGFRPDK2RAB9AKMT2A | |
| SCHEMBL9857813 | 0.76 | DHODH (0.37) | EGFRMEN1RAB9AKMT2AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0952974-B1 | BIPHENYL DERIVATIVES SUBSTITUTED BY AN AROMATIC OR HETEROAROMATIC RADICAL AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME | GALDERMA RES & DEV (FR) | 2001-11-21 | — | — | EP | disclosed |