Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.56 |
| ▸ | DRD3 | P35462 | 11/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790203 | 1.00 | DRD2 (0.56) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7790205 | 0.85 | DRD2 (0.53) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7790200 | 0.85 | DRD2 (0.53) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424155 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424159 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336392 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336396 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL11042776 | 0.74 | DRD2 (0.66) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL1682786 | 0.72 | DRD2 (1.00) | DRD2DRD3DRD4HTR1DHTR1A | |
| SCHEMBL17446169 | 0.72 | DRD2 (1.00) | DRD2DRD3DRD4HTR1DHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717620-B1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 2001-10-31 | — | — | EP | disclosed |
| US-5382596-A | Useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals | WHITBY RESEARCH, INC. (US) | 1995-01-17 | — | — | US | disclosed |