Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.53 |
| ▸ | DRD3 | P35462 | 13/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.53 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7790205 | 1.00 | DRD2 (0.53) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7790198 | 0.85 | DRD2 (0.56) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7790203 | 0.85 | DRD2 (0.56) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7933887 | 0.83 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7933885 | 0.83 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7785697 | 0.78 | ADRA1D (0.32) | DRD2DRD3DRD4ADRA1DADRA1A | |
| SCHEMBL7424155 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| SCHEMBL7424159 | 0.77 | DRD2 (0.71) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336396 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B | |
| Bromide SCHEMBL7336392 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0717620-B1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0717620-A4 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0717620-A1 | SUBSTITUTED 2-AMINOTETRALINS | Discovery Therapeutics, Inc. (US) | 1996-06-26 | — | — | EP | disclosed |
| WO-1995004532-A1 | SUBSTITUTED 2-AMINOTETRALINS | DISCOVERY THERAPEUTICS INC. (US) | 1995-02-16 | — | — | WO | disclosed |
| US-5382596-A | Useful for alleviating Parkinsonism, glaucoma, hyperprolactinemia and for inducing weight loss in mammals | WHITBY RESEARCH, INC. (US) | 1995-01-17 | — | — | US | disclosed |