Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.64 |
| ▸ | CA9 | Q16790 | 4/20 | 0.64 |
| ▸ | FDPS | P14324 | 4/20 | 0.62 |
| ▸ | MMP2 | P08253 | 9/20 | 0.62 |
| ▸ | CA1 | P00915 | 4/20 | 0.62 |
| ▸ | CA2 | P00918 | 3/20 | 0.62 |
| ▸ | MMP8 | P22894 | 8/20 | 0.60 |
| ▸ | MMP14 | P50281 | 7/20 | 0.60 |
| ▸ | MMP9 | P14780 | 4/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.56 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17187151 | 0.84 | MMP2 (0.83) | CA12CA9FDPSMMP2CA1 | |
| (Phenylamino)Methylenediphosphonic Acid SCHEMBL7796889 | 0.78 | CA12 (1.00) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL8159300 | 0.77 | FDPS (1.00) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL4088119 | 0.77 | MMP2 (1.00) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL8167824 | 0.76 | FDPS (0.44) | CA12CA9FDPSMMP2CA1 | |
| (P-Tolylamino)Methylenediphosphonic Acid SCHEMBL11570312 | 0.75 | CA12 (1.00) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL4088837 | 0.75 | MMP2 (0.68) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL17187031 | 0.72 | MMP2 (0.76) | CA12CA9FDPSMMP2CA1 | |
| SCHEMBL14241685 | 0.71 | FDPS (0.50) | FDPS | |
| SCHEMBL335444 | 0.71 | FDPS (0.50) | FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762883-B1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 2001-11-14 | — | — | EP | claimed |
| JP-54036273-A | — | — | None | — | — | JP | disclosed |
| US-5583122-A | TREATING DISEASES ASSOCIATED WITH ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | THE PROCTER & GAMBLE COMPANY (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0563107-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1993-10-06 | — | — | EP | disclosed |
| EP-0230068-B1 | USE OF A GEMINAL DIPHOSPHONIC ACID COMPOUND TO PREPARE A MEDICAMENT | Norwich Eaton Pharmaceuticals, Inc. (US) | 1992-07-15 | — | — | EP | disclosed |
| WO-1992011269-A1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 1992-07-09 | — | — | WO | disclosed |
| EP-0186405-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING GEMINAL DIPHOSPHONATES | THE PROCTER & GAMBLE COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4902679-A | TREATING BONE DISORDERS | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1990-02-20 | — | — | US | disclosed |
| EP-0186405-A2 | Pharmaceutical compositions containing geminal diphosphonates | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| US-4447256-A | POSTEMERGENCE HERBICIDE | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1984-05-08 | — | — | US | disclosed |
| JP-S5436273-A | N-PYRIDYL-AMINOMETHYLENE DISULFONIC ACID DERIVATIVES | NISSAN CHEM IND LTD | 1979-03-16 | — | — | JP | disclosed |
| US-3957160-A | Process for the prevention of precipitations in water or aqueous solutions | HENKEL & CIE G.M.B.H. (DT) | 1976-05-18 | — | — | US | disclosed |