Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 5/20 | 0.77 |
| ▸ | CES1 | P23141 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | APP | P05067 | 4/20 | 0.54 |
| ▸ | TDP2 | O95551 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | RAF1 | P04049 | 3/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | ARAF | P10398 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.50 |
| ▸ | MYOC | Q99972 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Iodoisatin SCHEMBL30794223 | 0.87 | TGM2 (1.00) | TGM2CES1MAPTAPPLRRK2 | |
| 5-Iodoisatin SCHEMBL75159 | 0.87 | TGM2 (1.00) | TGM2CES1MAPTAPPLRRK2 | |
| 5-Iodoisatin SCHEMBL28515786 | 0.85 | TGM2 (0.96) | TGM2CES1MAPTAPPLRRK2 | |
| 5-Iodoisatin SCHEMBL1482216 | 0.85 | TGM2 (0.96) | TGM2CES1MAPTAPPLRRK2 | |
| SCHEMBL20682550 | 0.84 | TGM2 (0.67) | TGM2CES1MAPTAPPTDP2 | |
| SCHEMBL23817603 | 0.79 | TGM2 (0.61) | TGM2CES1MAPTAPPLRRK2 | |
| SCHEMBL5740900 | 0.79 | TGM2 (0.61) | TGM2CES1MAPTAPPTDP2 | |
| SCHEMBL7332800 | 0.79 | TGM2 (0.56) | TGM2CES1MAPTAPPTDP2 | |
| SCHEMBL2144225 | 0.79 | PPOX (0.56) | TGM2CES1TDP2CYP3A4TDP1 | |
| SCHEMBL19338295 | 0.75 | TGM2 (0.52) | TGM2CES1MAPTAPPTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5726307-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| US-5583130-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0682654-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1996-01-17 | — | — | EP | disclosed |
| EP-0682654-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO. INC. (US) | 1995-11-22 | — | — | EP | disclosed |
| EP-0665747-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | MERCK & CO INC (US) | 1995-11-15 | — | — | EP | disclosed |
| EP-0665748-A4 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE. | — | 1995-08-23 | — | — | EP | disclosed |
| US-5317017-A | N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release | MERCK & CO., INC. (US) | 1994-05-31 | — | — | US | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1994007483-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| WO-1994007486-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-04-14 | — | — | WO | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5284841-A | Benzo-fused lactams promote release of growth hormone | MERCK & CO., INC. (US) | 1994-02-08 | — | — | US | disclosed |
| US-5283241-A | Animal growth regulators | MERCK & CO., INC. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |