Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 5/20 | 1.00 |
| ▸ | CES1 | P23141 | 5/20 | 1.00 |
| ▸ | MAOA | P21397 | 6/20 | 0.55 |
| ▸ | MAOB | P27338 | 6/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Iodoisatin SCHEMBL30794223 | 1.00 | TGM2 (1.00) | TGM2CES1MAOAMAOBCA12 | |
| 5-Iodoisatin SCHEMBL1482216 | 0.98 | TGM2 (0.96) | TGM2CES1MAOAMAOBCA12 | |
| 5-Iodoisatin SCHEMBL28515786 | 0.98 | TGM2 (0.96) | TGM2CES1MAOAMAOBCA12 | |
| SCHEMBL7791509 | 0.87 | TGM2 (0.77) | TGM2CES1LRRK2APPMAPT | |
| SCHEMBL3467211 | 0.83 | CES1 (0.71) | TGM2CES1MAOAMAOBCA12 | |
| SCHEMBL20682550 | 0.80 | TGM2 (0.67) | TGM2CES1MAOAMAOBLRRK2 | |
| SCHEMBL281743 | 0.77 | ROS1 (0.67) | TGM2CES1MAOAMAOBCA12 | |
| SCHEMBL29657257 | 0.77 | ROS1 (0.67) | TGM2CES1MAOAMAOBCA12 | |
| SCHEMBL23817603 | 0.76 | TGM2 (0.61) | TGM2CES1ALDH1A1LRRK2APP | |
| SCHEMBL5740900 | 0.76 | TGM2 (0.61) | TGM2CES1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 399 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368349-B | Novel N-substituted isatin derivative, preparation thereof and application thereof in preparation of antitumor drugs | 中国医学科学院药用植物研究所 | 2024-10-01 | — | — | CN | claimed |
| CN-117586485-A | Sulfonated hydrocarbon polymer containing protecting group, synthesis method and application thereof in low-temperature proton exchange membrane fuel cell | 中国科学院山西煤炭化学研究所 | 2024-02-23 | — | — | CN | claimed |
| CN-113912609-A | Preparation method of natural alkaloid tryptanthrin and derivative thereof | 江苏大学 | 2022-01-11 | — | — | CN | claimed |
| CN-111574426-A | Diamine monomer containing isoindigo structure and black polyimide synthesized from diamine monomer | 湘潭大学 | 2020-08-25 | — | — | CN | claimed |
| US-20150148292-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | UNIV EMORY (US) | 2015-05-28 | — | — | US | claimed |
| WO-2014011540-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | EMORY UNIVERSITY (US) | 2014-01-16 | — | — | WO | claimed |
| CN-102690226-A | Multi-nitrogen substituted isatin derivative and synthetic method of multi-nitrogen substituted isatin derivative | UNIV GUANGDONG TECHNOLOGY | 2012-09-26 | — | — | CN | claimed |
| US-6114540-A | COMBINATORIAL LIBRARIES | ARQULE, INC. (US) | 2000-09-05 | — | — | US | claimed |
| US-20260069173-A1 | ANALYTE SENSOR ELECTRODE ARRANGEMENTS | DEXCOM INC (US) | 2026-03-12 | — | — | US | disclosed |
| US-12495996-B2 | Analyte sensor electrode arrangements | DEXCOM, INC. (US) | 2025-12-16 | — | — | US | disclosed |
| CN-115368349-B | Novel N-substituted isatin derivative, preparation thereof and application thereof in preparation of antitumor drugs | 中国医学科学院药用植物研究所 | 2024-10-01 | — | — | CN | disclosed |
| US-12030877-B2 | Prostaglandin E synthase inhibitors and methods for utilizing the same | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2024-07-09 | — | — | US | disclosed |
| CN-117700407-A | 3, 3-disubstituted indol-2-one compound and preparation method and application thereof | 五邑大学 | 2024-03-15 | — | — | CN | disclosed |
| CN-117624174-A | Chiral [ oxindole-pyrrolidine-beta-lactam ] double-spiro compound containing trifluoromethyl, and preparation method and application thereof | 遵义医科大学 | 2024-03-01 | — | — | CN | disclosed |
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| US-5441955-A | Tuberculosis | PATHOGENESIS CORPORATION (US) | 1995-08-15 | — | — | US | disclosed |
| WO-1995013807-A1 | INDOLO[2,1-b]QUINAZOLINE-6,12-DIONE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF | PATHOGENESIS CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |
| US-4968702-A | ANTIARTHRITIC, INHIBITORS OF PROGRESSIVE JOINT DETERIORATION, IMMUNOSUPPRESSANT | AMERICAN CYANAMID COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0379145-A2 | Substituted quinolinecarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150148292-A1 | BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO | BMP4, BMP2, BMP1 | TGM2 1383/4885CES1 4616/4885MAOA 4630/4885 |
| US-20260069173-A1 | ANALYTE SENSOR ELECTRODE ARRANGEMENTS | SLC5A2, SLC5A1, CA2 | TGM2 692/4885CES1 2080/4885MAOA 3951/4885 |
| US-12030877-B2 | Prostaglandin E synthase inhibitors and methods for utilizing the same | PTGES, PTGS1, PTGES2 | TGM2 569/4885CES1 19/4885MAOA 350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.