Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 3/20 | 0.40 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.38 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519948 | 0.84 | KDM4E (0.40) | KDM4ENPC1RAB9AALDH1A1LMNA | |
| SCHEMBL7793618 | 0.82 | P4HTM (0.47) | KDM4EGAARAB9AKMT2AEPHX2 | |
| SCHEMBL7794298 | 0.82 | FDPS (0.60) | KDM4ETDP1FDPSFDFT1NPC1 | |
| SCHEMBL9223520 | 0.82 | KDM4E (0.44) | KDM4ECA12CA1CA2CA9 | |
| SCHEMBL7793195 | 0.82 | KDM4E (0.44) | KDM4EFDPSFDFT1DEGS1 | |
| SCHEMBL7793628 | 0.80 | FDPS (0.60) | CA12CA1CA2CA9FDPS | |
| SCHEMBL7790648 | 0.78 | KMT2A (0.49) | KDM4EGAACA1CA2NPC1 | |
| SCHEMBL8407752 | 0.76 | L3MBTL1 (0.40) | GAACA12CA1CA2CA9 | |
| SCHEMBL9226173 | 0.76 | KDM4E (0.39) | KDM4ETDP1FDPSFDFT1KMT2A | |
| SCHEMBL9220494 | 0.76 | KDM4E (0.39) | KDM4ETDP1FDPSFDFT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0762883-B1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 2001-11-14 | — | — | EP | claimed |
| EP-0762883-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033466-A1 | PYRIDYLBISPHOSPHONATES FOR USE AS A THERAPEUTICAL AGENT | LEIRAS OY (FI) | 1995-12-14 | — | — | WO | claimed |
| US-5866556-A | BONE DISORDERS | LEIRAS OY (FI) | 1999-02-02 | — | — | US | disclosed |