Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10227844 | 0.90 | NPC1 (0.48) | RAB9ANPC1SMN1; SMN2TP53KDM4E | |
| SCHEMBL76595 | 0.86 | KCNK3 (0.50) | RAB9ANPC1SMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL76387 | 0.84 | KCNK3 (0.47) | RAB9ANPC1SMN1; SMN2TP53TSHR | |
| SCHEMBL76896 | 0.82 | NPC1 (0.45) | RAB9ANPC1SMN1; SMN2TP53KCNK3 | |
| SCHEMBL10227845 | 0.80 | KCNK3 (0.54) | RAB9ANPC1KDM4EKCNK3KCNK9 | |
| SCHEMBL10227846 | 0.76 | ABCB1 (0.59) | RAB9ANPC1KMT2AKCNK3KCNK9 | |
| SCHEMBL25607328 | 0.70 | NPC1 (0.51) | RAB9ANPC1TP53TSHRMEN1 | |
| SCHEMBL5062430 | 0.69 | ABCB1 (0.65) | — | |
| SCHEMBL20090393 | 0.68 | CES2 (0.65) | RAB9ANPC1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL16857261 | 0.68 | GPR139 (0.59) | RAB9ANPC1SMN1; SMN2TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129355-B2 | Nuclear receptor-based inducible gene expression system; modulating the expression of a gene in a host cell by introducing into the host cell a gene expression modulation system and activating that system using 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid (1-benzoyl-cyclopentyl)-amide | INTREXON CORPORATION (US) | 2012-03-06 | — | — | US | disclosed |