SCHEMBL7794431

SCHEMBL7794431

COc1ccccc1C(=O)NS(=O)(=O)c1ccc([N+](=O)[O-])cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.58
KMT2A Q03164 1/20 0.58
MAPT P10636 3/20 0.57
ALDH1A1 P00352 1/20 0.57
LMNA P02545 1/20 0.57
PKM P14618 1/20 0.57
GAA P10253 2/20 0.55
RAB9A P51151 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
FLT1 P17948 5/20 0.54
FLT4 P35916 5/20 0.54
KDR P35968 5/20 0.54
POLB P06746 2/20 0.52
HPGD P15428 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
RXFP1 Q9HBX9 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6838339 0.85 FLT1 (0.53) MEN1KMT2AMAPTALDH1A1LMNA
SCHEMBL9414560 0.85 POLB (0.68) MEN1KMT2AMAPTGAARAB9A
SCHEMBL16244081 0.85 KDM4E (0.62) ALDH1A1GAARAB9ASMN1; SMN2FLT1
SCHEMBL7797528 0.83 GAA (0.59) MEN1KMT2AALDH1A1LMNAGAA
SCHEMBL16634981 0.82 GAA (0.57) KMT2AMAPTALDH1A1LMNAGAA
SCHEMBL3302654 0.81 FLT1 (0.57) LMNAGAARAB9ASMN1; SMN2FLT1
SCHEMBL28129967 0.81 GAA (0.60) ALDH1A1GAARAB9AFLT1FLT4
SCHEMBL18803129 0.81 POLB (0.64) LMNAGAARAB9ASMN1; SMN2FLT1
SCHEMBL26161946 0.81 GAA (0.56) KMT2AMAPTALDH1A1LMNAGAA
SCHEMBL27650215 0.80 GAA (0.55) GAARAB9ASMN1; SMN2FLT1FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912089-B1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE AVENTIS CROPSCIENCE GMBH (DE) 2001-11-28 EP disclosed
US-6235680-B1 REDUCING SIDE EFFECT OF PESTICIDE HOECHST SCHERING AGREVO GMBH (DE) 2001-05-22 US disclosed
EP-0912089-A1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE Hoechst Schering AgrEvo GmbH (DE) 1999-05-06 EP disclosed
WO-1997045016-A1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE HOECHST SCHERING AGREVO GMBH (DE) 1997-12-04 WO disclosed