SCHEMBL7794438

SCHEMBL7794438

O=C(NS(=O)(=O)c1ccc(N2C(=O)c3ccccc3C2=O)cc1)c1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.71
KMT2A Q03164 5/20 0.58
MEN1 O00255 4/20 0.58
LMNA P02545 2/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
FLT1 P17948 2/20 0.58
FLT4 P35916 2/20 0.58
KDR P35968 2/20 0.58
NPSR1 Q6W5P4 1/20 0.57
CA2 P00918 3/20 0.55
CA9 Q16790 3/20 0.55
CA12 O43570 2/20 0.55
CA1 P00915 2/20 0.55
SCN2A Q99250 2/20 0.55
POLB P06746 2/20 0.54
USP2 O75604 1/20 0.54
HTT P42858 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30268548 0.81 KDM4E (0.54) KDM4EKMT2AMEN1NPSR1CA2
SCHEMBL2587672 0.81 KDM4E (0.67) KDM4EKMT2AMEN1LMNAL3MBTL1
SCHEMBL174010 0.78 FLT1 (0.77) KDM4EKMT2AMEN1LMNAL3MBTL1
SCHEMBL5931087 0.77 PTGS2 (0.71) KMT2AMEN1LMNAL3MBTL1FLT1
SCHEMBL29011132 0.77 FLT1 (0.74) KDM4EKMT2AMEN1LMNAL3MBTL1
Potassium SCHEMBL30358590 0.77 FLT1 (0.74) KDM4EKMT2AMEN1LMNAL3MBTL1
SCHEMBL9920072 0.76 KDM4E (0.48) KDM4EKMT2AMEN1LMNAL3MBTL1
SCHEMBL16088828 0.76 NPSR1 (0.70) KDM4EKMT2AMEN1LMNANPSR1
SCHEMBL3292237 0.76 PTGS2 (0.69) KMT2AMEN1LMNAL3MBTL1FLT1
SCHEMBL8424044 0.76 FLT1 (0.73) KMT2AMEN1LMNAL3MBTL1FLT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912089-B1 NOVEL N-ACYL SULPHONAMIDES, NOVEL MIXTURES OF HERBICIDES AND ANTIDOTES AND THEIR USE AVENTIS CROPSCIENCE GMBH (DE) 2001-11-28 EP claimed