Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.39 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80509 | 0.87 | MTNR1A (0.37) | MTNR1AMTNR1BNPY2RHPGDPOLB | |
| SCHEMBL80086 | 0.87 | MTNR1A (0.42) | MTNR1AMTNR1BNPY2RHPGDKDM4E | |
| SCHEMBL11403283 | 0.79 | POLB (0.40) | MTNR1AMTNR1BNPY2RHPGDPOLB | |
| SCHEMBL11343622 | 0.76 | KMT2A (0.37) | NPY2RHPGDPOLBALDH1A1GAA | |
| SCHEMBL78628 | 0.76 | NPY2R (0.52) | NPY2RHPGDPOLBALDH1A1KDM4E | |
| SCHEMBL11856898 | 0.75 | MTNR1A (0.37) | MTNR1AMTNR1BNPY2RHPGDPOLB | |
| SCHEMBL79642 | 0.75 | MEN1 (0.36) | MTNR1AMTNR1BNPY2RHPGDPOLB | |
| SCHEMBL11851442 | 0.75 | MTNR1A (0.35) | MTNR1AMTNR1BNPY2RHPGDPOLB | |
| SCHEMBL78291 | 0.75 | RIPK1 (0.36) | MTNR1AMTNR1BNPY2RHPGDALDH1A1 | |
| SCHEMBL78353 | 0.74 | ALDH1A1 (0.40) | MTNR1AMTNR1BHPGDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8618162-B2 | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2013-12-31 | — | — | US | claimed |
| US-20120122970-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2012-05-17 | — | — | US | claimed |
| US-8618162-B2 | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120122970-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2012-05-17 | — | — | US | disclosed |
| US-8129428-B2 | Insecticidal carbamates exhibiting species-selective inhibition of acetylcholinesterase (AChE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2012-03-06 | — | — | US | disclosed |
| WO-2009036235-A2 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (ACHE) | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| US-20090068242-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068242-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | ACHE, BCHE, CHAT | MTNR1A 1417/4885MTNR1B 1547/4885NPY2R 2156/4885 |
| US-20120122970-A1 | INSECTICIDAL CARBAMATES EXHIBITING SPECIES-SELECTIVE INHIBITION OF ACETYLCHOLINESTERASE (AChE) | ACHE, BCHE, CHAT | MTNR1A 1417/4885MTNR1B 1547/4885NPY2R 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.