SCHEMBL7796467

SCHEMBL7796467

COc1c(C(=O)O)cc(C)cc1C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.45
TNFRSF1A P19438 2/20 0.44
ALDH1A1 P00352 3/20 0.42
CA2 P00918 1/20 0.42
POLB P06746 1/20 0.42
TYR P14679 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
RARG P13631 2/20 0.41
RXRA P19793 1/20 0.41
PPARG P37231 1/20 0.41
KDM4E B2RXH2 2/20 0.41
TDP1 Q9NUW8 2/20 0.40
TSHR P16473 1/20 0.40
RARA P10276 1/20 0.38
RARB P10826 1/20 0.38
CSNK2A1 P68400 1/20 0.38
GLRA3 O75311 1/20 0.38
GLRB P48167 1/20 0.38
HPGD P15428 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6736179 0.83 HSD17B10 (0.55) HSD17B10ALDH1A1POLBKDM4ETDP1
SCHEMBL5665923 0.83 RXRA (0.56) HSD17B10TNFRSF1ARARGRXRAPPARG
SCHEMBL5008844 0.82 HSD17B10 (0.47) HSD17B10TNFRSF1AALDH1A1CA2POLB
SCHEMBL7792928 0.82 RXRA (0.44) HSD17B10ALDH1A1CA2POLBTYR
SCHEMBL9192206 0.81 RXRA (0.55) HSD17B10TNFRSF1ARARGRXRAPPARG
SCHEMBL5857102 0.79 ALDH1A1 (0.52) HSD17B10TNFRSF1AALDH1A1CA2POLB
SCHEMBL5908087 0.79 RXRA (0.47) ALDH1A1SMN1; SMN2RARGRXRAPPARG
SCHEMBL7820121 0.78 HSD17B10 (0.50) HSD17B10ALDH1A1POLBSMN1; SMN2KDM4E
SCHEMBL10920134 0.78 KDM4E (0.55) HSD17B10ALDH1A1POLBKDM4ETDP1
SCHEMBL7941341 0.77 ALDH1A1 (0.37) HSD17B10TNFRSF1AALDH1A1CA2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0823435-B1 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL CO (JP) 2001-11-21 EP disclosed
US-6242514-B1 CYCLIC PHOSPHATE OR PHOSPHONATE; HEAT AND OXIDATION STABILIZER ESPECIALLY FOR OLEFIN POLYMERS AND ENGINEERING THERMOPLASTICS SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2001-06-05 US disclosed
US-5914361-A IMPART HEAT STABILITY TO ORGANIC MATERIALS, INCLUDING POLYOLEFINS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-06-22 US disclosed
US-5889095-A OXYGEN AND HEAT RESISTANCE SUMITOMO CHEMICAL COMPANY, LTD. (JP) 1999-03-30 US disclosed
EP-0823435-A2 Phosphites, process for producing the same and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-02-11 EP disclosed