Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7796728 | 0.82 | HDAC1 (0.53) | HDAC6HDAC1 | |
| SCHEMBL7796321 | 0.81 | HDAC6 (0.50) | HDAC6HDAC1SMN1; SMN2 | |
| SCHEMBL7796324 | 0.81 | HDAC6 (0.63) | HDAC6HDAC1TSHR | |
| SCHEMBL7796971 | 0.81 | ALDH1A1 (0.43) | HDAC6HDAC1LMNAMAPT | |
| SCHEMBL7795811 | 0.80 | POLB (0.40) | HDAC6HDAC1PRMT5WDR77LMNA | |
| SCHEMBL7796473 | 0.80 | L3MBTL1 (0.42) | HDAC6HDAC1SMN1; SMN2 | |
| SCHEMBL7787409 | 0.79 | HDAC6 (0.47) | HDAC6HDAC1PRMT5WDR77 | |
| SCHEMBL7797062 | 0.78 | HDAC1 (0.53) | HDAC6HDAC1MAPT | |
| SCHEMBL7787411 | 0.78 | HRH4 (0.48) | GAASMN1; SMN2MAPT | |
| SCHEMBL7796577 | 0.77 | HDAC1 (0.49) | HDAC6GAAHDAC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010151317-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-12-29 | — | — | WO | disclosed |