Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | MME | P08473 | 5/20 | 0.43 |
| ▸ | CPA1 | P15085 | 4/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.43 |
| ▸ | CTSC | P53634 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | IARS1 | P41252 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7133871 | 0.89 | PLAU (0.40) | ACEMMECPA1ACE2SMN1; SMN2 | |
| SCHEMBL7136265 | 0.85 | MEN1 (0.48) | ACEMMECPA1ACE2SMN1; SMN2 | |
| SCHEMBL7131866 | 0.84 | CASP1 (0.46) | CTSCCASP1CTSLCTSBCTSS | |
| SCHEMBL7139496 | 0.83 | HPGD (0.48) | ACEMMECPA1ACE2SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7140699 | 0.83 | CASP1 (0.45) | CTSCCASP1CTSLCTSBCTSS | |
| SCHEMBL7136919 | 0.81 | MEN1 (0.44) | CASP1CTSLCTSBCTSS | |
| SCHEMBL7138103 | 0.81 | CTSS (0.51) | CTSLCTSBCTSS | |
| SCHEMBL7133678 | 0.81 | CTSL (0.38) | ACEMMECPA1ACE2SMN1; SMN2 | |
| SCHEMBL7139696 | 0.79 | LNPEP (0.43) | SMN1; SMN2CTSLCTSBCTSS | |
| SCHEMBL7135424 | 0.79 | LNPEP (0.41) | ACEMMECPA1ACE2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159260-A1 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000055124-A2 | NOVEL COMPOUNDS AND COMPOSITIONS AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |