Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 15/20 | 0.61 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FDFT1 | P37268 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isaxonine SCHEMBL4537710 | 0.77 | FDPS (0.42) | FDPS | |
| SCHEMBL5156538 | 0.76 | FDPS (1.00) | FDPSCA12CA9FDFT1 | |
| SCHEMBL7790447 | 0.74 | FDPS (0.69) | FDPSCA12CA9 | |
| SCHEMBL7790669 | 0.72 | FDPS (0.54) | FDPSCA12CA9FDFT1MMP8 | |
| SCHEMBL15163986 | 0.72 | FDPS (0.67) | FDPSCA12CA9FDFT1MMP8 | |
| SCHEMBL8167477 | 0.72 | FDPS (1.00) | FDPSCA12CA9FDFT1MMP8 | |
| SCHEMBL9790674 | 0.72 | FDPS (0.44) | FDPSCA12CA9FDFT1MMP8 | |
| SCHEMBL17187256 | 0.72 | FDPS (0.46) | FDPSCA12CA9FDFT1MMP8 | |
| SCHEMBL9219549 | 0.71 | FDPS (0.38) | FDPS | |
| SCHEMBL19468538 | 0.69 | FDPS (0.65) | FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186405-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING GEMINAL DIPHOSPHONATES | THE PROCTER & GAMBLE COMPANY (US) | 1991-03-06 | — | — | EP | claimed |
| EP-0186405-A2 | Pharmaceutical compositions containing geminal diphosphonates | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-02 | — | — | EP | claimed |
| JP-54144383-A | — | — | None | — | — | JP | disclosed |
| US-6329354-B1 | ADMINISTERING BONE ACTIVE PHOSPHONATE, ADMINISTERING ESTROGEN HORMONE | THE PROCTER & GAMBLE COMPANY | 2001-12-11 | — | — | US | disclosed |
| EP-1158987-A1 | METHODS OF INCREASING BONE VOLUME USING NON-NATURALLY-OCCURRING FP SELECTIVE AGONISTS AND ANTIRESORPTIVE COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051617-A1 | METHODS OF INCREASING BONE VOLUME USING NON-NATURALLY-OCCURRING FP SELECTIVE AGONISTS AND ANTIRESORPTIVE COMPOUNDS | THE PROCTER & GAMBLE COMPANY (US) | 2000-09-08 | — | — | WO | disclosed |
| US-5869471-A | Methods for the treatment of arthritis using phosphonates and NSAIDS | THE PROCTOR & GAMBLE COMPANY (US) | 1999-02-09 | — | — | US | disclosed |
| EP-0779813-A4 | PHOSPHONATES AND PARATHYROID HORMONE FOR OSTEOPOROSIS | PROCTER & GAMBLE (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0648120-B1 | USE OF PHOSPHONATES FOR THE TREATMENT OF OSTEOPOROSIS | PROCTER & GAMBLE PHARMA (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0779812-A4 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BONE ACTIVE PHOSPHONATES AND PARATHYROID HORMONE | PROCTER & GAMBLE (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0779812-A1 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BONE ACTIVE PHOSPHONATES AND PARATHYROID HORMONE | THE PROCTER & GAMBLE COMPANY (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1994000129-A1 | USE OF PHOSPHONATES FOR THE TREATMENT OF OSTEOPOROSIS | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| WO-1993011786-A1 | METHODS FOR THE TREATMENT OF OSTEOPOROSIS USING BISPHOSPHONATES AND PARATHYROID HORMONE | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1993-06-24 | — | — | WO | disclosed |
| WO-1992021355-A1 | CALCIUM, TRACE MINERAL, VITAMIN D AND DRUG THERAPY COMBINATIONS | THE PROCTER & GAMBLE COMPANY (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0186405-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING GEMINAL DIPHOSPHONATES | THE PROCTER & GAMBLE COMPANY (US) | 1991-03-06 | — | — | EP | disclosed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |
| US-4761406-A | ADMINISTERING A ONE RESORPTION INHIBITING POLYPHOSPHONATE | THE PROCTER & GAMBLE COMPANY (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0210728-A2 | Kit containing polyphosphonate for treating osteoporosis | THE PROCTER & GAMBLE COMPANY (US) | 1987-02-04 | — | — | EP | disclosed |
| EP-0186405-A2 | Pharmaceutical compositions containing geminal diphosphonates | THE PROCTER & GAMBLE COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| JP-S54144383-A | DIPHOSPHONIC ACID DERIVATIVE AND HERBICIDE CONTAINING THE SAME | NISSAN CHEM IND LTD | 1979-11-10 | — | — | JP | disclosed |