Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | KIF5B | P33176 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7766729 | 0.82 | MEN1 (0.46) | KDM4EALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL7799373 | 0.82 | EGFR (0.44) | KDM4EALDH1A1SMN1; SMN2FGFR1LRRK2 | |
| SCHEMBL7799232 | 0.81 | CSF1R (0.49) | KDM4EALDH1A1SMN1; SMN2FGFR1LRRK2 | |
| SCHEMBL7754110 | 0.80 | EGFR (0.54) | KDM4EALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL7790969 | 0.80 | EGFR (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTFGFR1 | |
| SCHEMBL7797258 | 0.79 | KDR (0.59) | KDM4EALDH1A1SMN1; SMN2FGFR1LRRK2 | |
| SCHEMBL7595199 | 0.79 | PDGFRB (0.43) | KDM4EALDH1A1SMN1; SMN2FGFR1LRRK2 | |
| SCHEMBL7791030 | 0.74 | FLT1 (0.55) | KDM4EALDH1A1SMN1; SMN2FGFR1LRRK2 | |
| SCHEMBL7800417 | 0.74 | LRRK2 (0.53) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL1539121 | 0.74 | RET (0.55) | KDM4EALDH1A1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1162974-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | Parker Hughes Institute (US) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056338-A1 | QUINAZOLINE FORMULATIONS AND THERAPEUTIC USE THEREOF | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |