Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595199 | 0.86 | PDGFRB (0.43) | SMN1; SMN2KDM4EALDH1A1PDGFRBPDGFRA | |
| SCHEMBL7790969 | 0.85 | EGFR (0.55) | MAPTSMN1; SMN2KDM4EALDH1A1IGF1R | |
| SCHEMBL7797381 | 0.82 | KDM4E (0.43) | MEN1POLBKMT2AMAPTTP53 | |
| SCHEMBL7799373 | 0.80 | EGFR (0.44) | SMN1; SMN2KDM4EALDH1A1IGF1RKDR | |
| SCHEMBL7797258 | 0.79 | KDR (0.59) | SMN1; SMN2KDM4EALDH1A1PDGFRBPDGFRA | |
| SCHEMBL7799232 | 0.78 | CSF1R (0.49) | SMN1; SMN2KDM4EALDH1A1SLC2A1EGFR | |
| SCHEMBL7754110 | 0.78 | EGFR (0.54) | MEN1POLBKMT2AMAPTTP53 | |
| SCHEMBL5446668 | 0.76 | RAF1 (0.50) | MEN1POLBKMT2AMAPTTP53 | |
| SCHEMBL7791030 | 0.74 | FLT1 (0.55) | SMN1; SMN2KDM4EALDH1A1KDREGFR | |
| SCHEMBL7791014 | 0.74 | C1R (0.51) | KMT2AMAPTSMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100787-A1 | LIPID-LOWERING QUINAZOLINE DERIVATIVE | Parker Hughes Institute (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006554-A1 | LIPID-LOWERING QUINAZOLINE DERIVATIVE | PARKER HUGHES INSTITUTE (US) | 2000-02-10 | — | — | WO | disclosed |