SCHEMBL7797786

SCHEMBL7797786

O=C(c1ccc(F)cc1F)C(F)(F)CCOCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 2/20 0.43
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
CTSB P07858 1/20 0.39
CHRM3 P20309 2/20 0.39
MAOB P27338 2/20 0.38
AR P10275 1/20 0.38
PPIA P62937 1/20 0.37
NPC1 O15118 1/20 0.37
POLB P06746 1/20 0.37
RAB9A P51151 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7797782 0.82 GRM5 (0.41) GRM5CES2CES1CTSBCHRM3
SCHEMBL7803050 0.82 CES2 (0.44) CES2CES1MAOBPOLBRAB9A
SCHEMBL7803908 0.77 GRM5 (0.45) GRM5CES2CES1CTSBPOLB
SCHEMBL7804478 0.76 CES2 (0.44) CES2CES1MAOBNPC1POLB
SCHEMBL7803902 0.74 GRM5 (0.42) GRM5CES2CES1CTSBCHRM3
SCHEMBL522838 0.73 ALDH1A1 (0.57) CES2CES1POLBRAB9A
SCHEMBL9116753 0.72 TSHR (0.48) CES1POLB
SCHEMBL6945689 0.70 CES2 (0.53) CES2CES1
SCHEMBL28675737 0.69 MMP8 (0.48) POLB
SCHEMBL8743553 0.69 KDM4E (0.50) CES1CHRM3POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0814079-B1 Triazole derivative or salt thereof SS PHARMACEUTICAL CO (JP) 2001-03-28 EP disclosed
US-6063945-A FUNGICIDES SS PHARMACEUTICAL CO., LTD. (JP) 2000-05-16 US disclosed
US-5939448-A ANTIMYCOTIC AGENT SS PHARMACEUTICAL CO., LTD. (JP) 1999-08-17 US disclosed
EP-0814079-A1 Triazole derivative or salt thereof SS PHARMACEUTICAL CO., LTD. (JP) 1997-12-29 EP disclosed