Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of 2-Naphthaldehyde. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 4/20 | 0.38 |
| ▸ | PPARA | Q07869 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTR1E | P28566 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Naphthaldehyde SCHEMBL7797994 | 0.89 | RAB9A (0.41) | EPHX1CNR2L3MBTL1FAAHLMNA | |
| 2-Naphthaldehyde SCHEMBL8035922 | 0.88 | GRIK1 (0.46) | GRIK1GRIK2GRIK3EPHX1PPARG | |
| 2-Naphthaldehyde SCHEMBL8035927 | 0.88 | GRIK1 (0.46) | GRIK1GRIK2GRIK3EPHX1PPARG | |
| 2-Naphthaldehyde SCHEMBL8213735 | 0.86 | GRIK1 (0.48) | GRIK1GRIK2GRIK3L3MBTL1HCAR2 | |
| Benzaldehyde SCHEMBL7798223 | 0.85 | ALDH1A1 (0.44) | L3MBTL1MEN1KMT2ARAB9A | |
| 2-Naphthaldehyde SCHEMBL8025531 | 0.83 | GRIK1 (0.43) | GRIK1GRIK2GRIK3EPHX1PPARG | |
| 2-Naphthaldehyde SCHEMBL8025528 | 0.83 | GRIK1 (0.43) | GRIK1GRIK2GRIK3EPHX1PPARG | |
| Cyclohexylamine SCHEMBL7802055 | 0.83 | RAB9A (0.53) | FAAHMEN1KMT2ARAB9A | |
| Cyclohexylamine SCHEMBL7799139 | 0.83 | SMYD3 (0.42) | EPHX1PPARGPPARAMEN1KMT2A | |
| Cyclohexylamine SCHEMBL7800175 | 0.82 | PARP10 (0.44) | EPHX1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |