Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | CCR3 | P51677 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8021851 | 0.99 | SLC6A2 (0.46) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B | |
| SCHEMBL7808775 | 0.86 | P2RX7 (0.44) | SIGMAR1 | |
| SCHEMBL7807144 | 0.85 | HTR1D (0.56) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B | |
| Hydrochloric Acid SCHEMBL8035076 | 0.85 | P2RX7 (0.44) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8033570 | 0.84 | HTR1D (0.55) | SLC6A2SLC6A4SIGMAR1CCR3KCNH2 | |
| SCHEMBL7808759 | 0.81 | SIGMAR1 (0.52) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B | |
| SCHEMBL7804160 | 0.79 | HTR1D (0.56) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B | |
| Hydrochloric Acid SCHEMBL8032981 | 0.78 | HTR1D (0.55) | SLC6A2SLC6A4SIGMAR1CCR3KCNH2 | |
| SCHEMBL7808734 | 0.77 | MEN1 (0.56) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B | |
| SCHEMBL7798285 | 0.75 | SLC6A2 (0.50) | SLC6A2SLC6A4SIGMAR1CCR3GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |