Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8035076 | 0.99 | P2RX7 (0.44) | P2RX7SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL7798113 | 0.86 | SLC6A2 (0.47) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8021851 | 0.85 | SLC6A2 (0.46) | SIGMAR1 | |
| SCHEMBL7804093 | 0.84 | HTR1D (0.54) | P2RX7SIGMAR1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8021793 | 0.83 | HTR1D (0.53) | P2RX7SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL7804946 | 0.82 | P2RX7 (0.44) | P2RX7SIGMAR1CASP1CASP4CASP5 | |
| Hydrochloric Acid SCHEMBL8031207 | 0.81 | P2RX7 (0.43) | P2RX7SIGMAR1CASP1CASP4CASP5 | |
| SCHEMBL7808717 | 0.80 | SIGMAR1 (0.61) | P2RX7SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL7806993 | 0.77 | HTR1D (0.54) | P2RX7SIGMAR1DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8033577 | 0.77 | HTR1D (0.53) | P2RX7SIGMAR1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |