Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | CCR3 | P51677 | 2/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8021878 | 0.99 | SLC6A2 (0.49) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| SCHEMBL7804094 | 0.85 | HTR6 (0.49) | SIGMAR1HTR1DHTR1BDRD4CHRM2 | |
| Hydrochloric Acid SCHEMBL8031680 | 0.84 | HTR6 (0.48) | SIGMAR1HTR1DHTR1BDRD4CHRM2 | |
| SCHEMBL7804160 | 0.80 | HTR1D (0.56) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| SCHEMBL7807144 | 0.80 | HTR1D (0.56) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| Hydrochloric Acid SCHEMBL8033570 | 0.79 | HTR1D (0.55) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| Hydrochloric Acid SCHEMBL8032981 | 0.79 | HTR1D (0.55) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| SCHEMBL7798136 | 0.76 | SLC6A2 (0.50) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| Hydrochloric Acid SCHEMBL8031601 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4SIGMAR1CCR3HTR1D | |
| SCHEMBL7798113 | 0.75 | SLC6A2 (0.47) | SLC6A2SLC6A4SIGMAR1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |