Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8031680 | 0.99 | HTR6 (0.48) | HTR6BCHEHTR1DHTR1BSIGMAR1 | |
| SCHEMBL7798285 | 0.85 | SLC6A2 (0.50) | HTR1DHTR1BSIGMAR1DRD2CHRM2 | |
| Hydrochloric Acid SCHEMBL8021878 | 0.84 | SLC6A2 (0.49) | HTR1DHTR1BSIGMAR1DRD2CHRM2 | |
| SCHEMBL7806993 | 0.78 | HTR1D (0.54) | HTR1DHTR1BSIGMAR1P2RX7DRD2 | |
| SCHEMBL7804093 | 0.78 | HTR1D (0.54) | HTR1DHTR1BSIGMAR1P2RX7DRD2 | |
| Hydrochloric Acid SCHEMBL8021793 | 0.77 | HTR1D (0.53) | HTR1DHTR1BSIGMAR1P2RX7DRD2 | |
| Hydrochloric Acid SCHEMBL8033577 | 0.77 | HTR1D (0.53) | HTR1DHTR1BSIGMAR1P2RX7DRD2 | |
| SCHEMBL7798184 | 0.73 | SLC6A2 (0.43) | HTR1DHTR1BSIGMAR1P2RX7DRD2 | |
| SCHEMBL7808775 | 0.73 | P2RX7 (0.44) | SIGMAR1P2RX7DRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL8021881 | 0.73 | SLC6A2 (0.42) | HTR1DHTR1BSIGMAR1P2RX7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |